Enable JavaScript to run this app.
Skip to main content
OpenTable logo
Food - Rx Restaurant, Wilmington, NC

Rx Restaurant

4.7 (912)
$30 and under
Southern
421 Castle St, Wilmington, NC 28401

About this restaurant

  • Innovative
  • Romantic
  • Good for special occasions
Located in the Castle Street Art District in Wilmington, NC, Rx Restaurant and Bar is here to serve the best local ingredients around. Our chef is committed to bringing fresh food to your table, so the menu changes daily based on what he can find locally. Parking is free on Castle Street as well as in the parking lot diagonal from us on 5th and Castle!

Not available on OpenTable

Unfortunately, this restaurant is not on the OpenTable booking network. To check availability, please contact them directly.

Is this your restaurant?
Claim this listing

There’s more to explore

Discover countless more restaurants like this one with our app.

Scan the QR code to discover countless more restaurants like this one with our app.

Open app

Additional information

  • Dining style
    Casual Dining
  • Price
    $30 and under
  • Cuisines
    Southern
  • Hours of operation
    Tue–Sat 5:00 pm–9:00 pm Sun 10:00 am–2:00 pm
  • Payment options
    AMEX, Diners Club, Discover, Mastercard, Visa
  • Dress code
    Casual Dress
  • Executive chef
    James Doss
  • Neighborhood
    Wilmington
  • Cross street
    421 castle st
  • Parking details
    Parking is free on Castle Street as well as in the large parking lot diagonal from the restaurant!
  • Additional
    Bar/Lounge, Beer, BYO Wine, Cocktails, Corkage Fee, Full Bar, Gender Neutral Restroom, Gluten-free Options, Non-Smoking, View, Weekend Brunch, Wheelchair Access, Wine

Reviews

OpenTable reviews from verified diners

Reviews from people who have dined at Rx Restaurant.

4.7

4.7
(912)
  • 4.7Food
  • 4.7Service
  • 4.4Ambience
  • 3.6Value

Noise • Moderate

912 Reviews
  1. OpenTable Diner

    Nashville3 reviews

    5.0

    Dined on November 9, 2019

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Great food and customer service!

    Is this helpful?

  2. JerryW

    Key West6 reviews

    4.0

    Dined on November 1, 2019

    1. Overall 4
    2. Food 4
    3. Service 5
    4. Ambience 4
    Good but loud.

    Is this helpful?

  3. OpenTable Diner

    Greensboro9 reviews

    4.0

    Dined on October 24, 2019

    1. Overall 4
    2. Food 3
    3. Service 5
    4. Ambience 3
    imaginative offerings but entrees featuring pork & trigger fish were incredibly salty- this was unlike our previous experience a couple of years ago

    Is this helpful?

  4. SusanL Gold

    Wilmington34 reviews

    5.0

    Dined on October 23, 2019

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Outstanding as always. This is our favorite restaurant in town

    Is this helpful?

  5. BFG54 Gold

    Raleigh24 reviews

    5.0

    Dined on October 19, 2019

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Menu was great with numerous unique offerings. Food taste/quality/freshness superb. Service was flawless. Parking was a breeze. Ambiance was spot on for decor and setup. Noise level was high and for our table of 5 it was hard to hear the waiter when he was at the other end of the table. Some noise absorbing materials would be a good addition. Regardless we will be back.

    Is this helpful?

  6. KathyC

    New York City5 reviews

    5.0

    Dined on October 13, 2019

    1. Overall 5
    2. Food 4
    3. Service 5
    4. Ambience 4
    Always enjoy Rx Sunday brunch! Great staff, good food. Happy to be there!

    Is this helpful?

  7. MichaelK Gold

    Wilmington184 reviews

    5.0

    Dined on October 12, 2019

    1. Overall 5
    2. Food 4
    3. Service 5
    4. Ambience 4
    Great as usual, Rick still best waiter in town.

    Is this helpful?

  8. OpenTable Diner

    New York City3 reviews

    4.0

    Dined on October 12, 2019

    1. Overall 4
    2. Food 4
    3. Service 5
    4. Ambience 4
    This was our first time dining at Rx, and we enjoyed the experience. We got a call a few hours before our reservation to confirm that we were coming and were asked if we were celebrating anything special that evening. I mentioned that it was my husband’s birthday, and that night when we were seated and handed a menu, a birthday greeting was across the top - a special touch and much appreciated! Service was great, and the food, on the whole, was quite delicious. For appetizers, we had the deviled eggs and fried okra - both great. The two couples ordered the same thing - shrimp and grits for the ladies and pork shoulder for the gentlemen. The shrimp and grits were delicious, but one of the pork shoulders was deemed a bit tough, though tastefully seasoned. Desserts were apple tart with ice cream and pear cake with maple frosting - yummy! Looking forward to a return visit!

    Is this helpful?

  9. DresM

    San Francisco4 reviews

    5.0

    Dined on October 10, 2019

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Have eaten at Rx many, probably the best meal we have ever had their!

    Is this helpful?

  10. AutumnMac

    Wilmington17 reviews

    5.0

    Dined on October 9, 2019

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Outstanding dining experience ~ but we expected nothing less! Our waiter Miguel was wonderful from the moment we sat down ~ he was attentive when needed, and at no time were we rushed & the meal was wonderfully paced. Food, cocktails & wine was superior! I was so excited that we were there on a night when Rx had buffalo wing pigs ears on the menu! A treat not to miss treat! It was a perfect evening celebrating our anniversary!

    Is this helpful?

Additional information

  • Dining style
    Casual Dining
  • Price
    $30 and under
  • Cuisines
    Southern
  • Hours of operation
    Tue–Sat 5:00 pm–9:00 pm Sun 10:00 am–2:00 pm
  • Payment options
    AMEX, Diners Club, Discover, Mastercard, Visa
  • Dress code
    Casual Dress
  • Executive chef
    James Doss
  • Neighborhood
    Wilmington
  • Cross street
    421 castle st
  • Parking details
    Parking is free on Castle Street as well as in the large parking lot diagonal from the restaurant!
  • Additional
    Bar/Lounge, Beer, BYO Wine, Cocktails, Corkage Fee, Full Bar, Gender Neutral Restroom, Gluten-free Options, Non-Smoking, View, Weekend Brunch, Wheelchair Access, Wine
  1. Home
  2. United States
  3. Coastal North Carolina
  4. Wilmington
  5. Wilmington

Not available on OpenTable

Unfortunately, this restaurant is not on the OpenTable booking network. To check availability, please contact them directly.

Is this your restaurant?
Claim this listing
Discover
OpenTable
  • About Us
  • Blog
  • Careers
  • Press
More
Businesses
  • Restaurant Management Solutions
  • Restaurant Reservation Software
  • Restaurant Marketing Software
  • Restaurant Event Software
  • OpenTable For Restaurants
  • OpenTable For Restaurant Groups
  • OpenTable Pricing & Plans
Join us on
  • Privacy Policy
  • Terms of Use
  • Cookies and Interest-Based Ads
  • Accessibility Statement
  • Cookie Preferences
Copyright © 2026 OpenTable, Inc. 425 Market St Ste 1200, San Francisco CA 94105 - All rights reserved.
OpenTable is part of Booking Holdings, the world leader in online travel and related services.
Booking Logo
Priceline Logo
KAYAK Logo
Agoda Logo
OpenTable Logo