Enable JavaScript to run this app.
Skip to main content
OpenTable logo
  1. Home
  2. United States
  3. South Carolina

Best Seafood Restaurants in Lake City, South Carolina

Price
Regions
Neighborhoods
Dining Options
Seating Options
Accessibility

18 restaurants available nearby

How are Featured results ranked

A photo of Red Lobster - Florence - David McLeod Blvd. restaurant
1. Red Lobster - Florence - David McLeod Blvd.
2.9
(11)
$$$$
• Seafood • Florence
At Red Lobster, we don’t just serve your seafood favorites—we serve an experience that makes you want to come back for more. That can’t-stop-smiling, pass-the-Cheddar Bay Biscuits kind of happy. It’s the joy that comes when the lobster hits the table, the shrimp hits just right, or you get the perfect crack on your crab leg. Whether you’re celebrating a milestone or just indulging on any given day, every visit feels like an occasion even if there isn’t one. So pull up a chair, grab a biscuit (or three). We’ve got delicious seafood, smiles, and good vibes. Come taste what we’re all about at your local Red Lobster today.
A photo of Gulfstream Cafe - Priority Seating restaurant
2. Gulfstream Cafe - Priority Seating
4.5
Awesome(5105)
$$$$
• Seafood • Garden City/Murrells Inlet
Booked 58 times today
Gulfstream Cafe - Priority Seating stands out as a paragon of authentic American coastal cuisine, nestled in the picturesque Garden City. Renowned for its fresh seafood and Southern favorites, this cherished locale promises a memorable dining experience. "Always a favorite," diners rave about the "fantastic views, food, and service," making it a must-visit on the Grand Strand. The menu's highlights, such as the Grouper Francaise and She Crab Soup, are consistently praised for their deliciousness. With breathtaking sunset views over Murrells Inlet, Gulfstream Cafe offers a delightful blend of taste and scenery, ensuring every visit is "an outstanding experience!"
A photo of Aspen Grille restaurant
3. Aspen Grille
4.9
Exceptional(3514)
$$$$
• Seafood • Myrtle Beach
Booked 23 times today
Aspen Grille in Myrtle Beach is a seafood lover's paradise, offering dishes that are not only fresh but also exquisitely prepared. Diners rave about the seafood, with one guest declaring, "The sea bass was wonderful and perfectly prepared." The restaurant's commitment to sourcing the best local ingredients ensures an authentic and high-quality dining experience. Whether it's the perfectly cooked halibut or the scallops that are "out of this world," every dish is a testament to their culinary expertise. Aspen Grille's seasonal menu paired with a Wine Spectator Award-winning wine list makes it a must-visit destination for seafood aficionados.
A photo of New York Prime Steakhouse - Myrtle Beach restaurant
4. New York Prime Steakhouse - Myrtle Beach
4.8
Exceptional(4541)
$$$$
• Seafood • Myrtle Beach
Booked 46 times today
New York Prime Steakhouse in Myrtle Beach offers an unforgettable seafood dining experience, where the "fresh Florida stone crabs" and "colossal baked shrimp" are the true stars of the show. Despite its reputation as a steakhouse, the seafood offerings are equally impressive, showcasing the restaurant's commitment to quality and authenticity. Guests rave about the seafood bisque and shrimp cocktail, noting their "delicious" flavors and perfect presentation. The seafood dishes are meticulously prepared, ensuring that each bite is a testament to the ocean's bounty. Whether you're a local or a visitor, New York Prime promises a seafood feast that is "absolutely amazing."
A photo of Hot Fish Club restaurant
5. Hot Fish Club
4.8
Exceptional(2685)
$$$$
• Seafood • Garden City/Murrells Inlet
Booked 26 times today
The Hot Fish Club in Murrells Inlet is a beacon of outstanding American cuisine, offering diners an authentic experience steeped in history and flavor. Renowned for its "amazing grouper and filet mignon," this restaurant consistently delivers dishes that exceed expectations, making it a favorite for both locals and visitors. Guests rave about the "lobster pot pie" and "sea bass," highlighting the exceptional quality and taste. The Hot Fish Club's dedication to "great food, great drink, and lively conversation" ensures every visit is memorable. Whether you're enjoying the beautiful views or the vibrant atmosphere, this is truly a must-visit spot for American cuisine aficionados.
A photo of Perrone's Restaurant and Bar restaurant
6. Perrone's Restaurant and Bar
4.9
Exceptional(549)
$$$$
• Seafood • Pawleys Island
Booked 17 times today
Perrone's Restaurant and Bar in Pawleys Island offers an exceptional Mediterranean dining experience that delights the senses and keeps patrons coming back for more. Known for its "creative and delicious" dishes, Perrone’s elevates Mediterranean cuisine with an innovative menu that showcases responsibly sourced, fresh local seafood and exquisite USDA Prime dry-aged beef. The "unbelievable evening" guests experience is complemented by an award-winning wine list and unique craft cocktails. The ambiance is chic yet relaxed, with local art, low lighting, and soothing jazz music creating a welcoming atmosphere. As one delighted diner expressed, "The food was fabulous and the service was spectacular," making Perrone's a must-visit destination for Mediterranean cuisine enthusiasts.
A photo of Landry's Seafood House - Myrtle Beach restaurant
7. Landry's Seafood House - Myrtle Beach
4.1
Excellent(2216)
$$$$
• Seafood • Myrtle Beach
Booked 48 times today
Landry's Seafood House in Myrtle Beach is a shining example of exquisite American cuisine, perfectly marrying the warmth and tradition of the Gulf Coast with top-notch service. Diners rave about the "delicious quality food" and "excellent cocktails," highlighting the freshness and perfection of each dish. With impeccable service and a warm, inviting atmosphere, patrons are consistently impressed by the "phenomenal" dining experience. The restaurant’s commitment to authenticity is evident in standout dishes like the Shrimp Embrochette and Snapper Hemingway, which transport guests to the heart of American coastal flavors. Whether it's a special occasion or a casual night out, Landry's promises a memorable experience.
A photo of The Independent restaurant
8. The Independent
4.7
Exceptional(639)
$$$$
• Seafood • Georgetown
Booked 20 times today
The Independent in Georgetown is a true gem for lovers of authentic American cuisine, particularly those with a penchant for the Lowcountry's seafood bounty. This vibrant restaurant beautifully marries Southern-inspired dishes with the freshest local ingredients, making each meal a celebration of the region's culinary heritage. Guests rave about the "phenomenal" flavors, from the "superb" shrimp and grits to the "best char on swordfish" they've ever tasted. The attentive service adds to the allure, with staff making every occasion special, as noted in reviews about their thoughtful touches for anniversaries and birthdays. The Independent is a must-visit for an exceptional American dining experience.
A photo of California Dreaming - Surfside Beach restaurant
9. California Dreaming - Surfside Beach
4.5
Awesome(1233)
$$$$
• Seafood • Myrtle Beach
Booked 18 times today
California Dreaming - Surfside Beach is a shining gem for Seafood enthusiasts in Myrtle Beach. Known for its fresh, made-from-scratch dishes, it delivers authentic flavors that captivate your taste buds. Guests rave about the "phenomenal Cali bowl with tuna poke," highlighting the restaurant's commitment to quality and taste. The She Crab soup is another favorite, described as "delicious and substantial," providing a true taste of the sea. With a warm, family-friendly atmosphere and attentive service, California Dreaming provides a delightful seafood dining experience that is consistently praised by locals and visitors alike. Dive into a culinary journey that promises excellence with every bite!
A photo of O.A.K. Prime Kitchen and Bar restaurant
10. O.A.K. Prime Kitchen and Bar
4.7
Exceptional(488)
$$$$
• Seafood • Myrtle Beach
Booked 14 times today
O.A.K. Prime Kitchen and Bar in Myrtle Beach is a seafood lover's paradise, celebrated for its exquisite and authentic seafood offerings. Diners rave about the "delicious and unique" smoked oysters and the perfectly cooked Chilean sea bass, which many describe as "absolutely divine." The culinary expertise of Chef JK shines through in every dish, with reviewers consistently praising the "exceptional" and "outstanding" quality of the food. The restaurant's warm and inviting atmosphere, combined with attentive and knowledgeable staff, makes it the ideal spot for a memorable dining experience. If you're seeking top-tier seafood in Myrtle Beach, O.A.K. Prime is a must-visit!
‘About the restaurant’ descriptions have been generated using an artificial intelligence model comprised of OpenTable proprietary data that has not been independently verified by OpenTable. The content is presented as-is, for informational purposes only.

See what locals rave about

From verified diners like you
From verified diners like you

Explore OpenTable

Discover
OpenTable
  • About Us
  • Blog
  • Careers
  • Press
More
Our sites
Businesses
  • Restaurant Management Solutions
  • Restaurant Reservation Software
  • Restaurant Marketing Software
  • Restaurant Event Software
  • OpenTable For Restaurants
  • OpenTable For Restaurant Groups
  • OpenTable Pricing & Plans
Join us on
  • Privacy Policy
  • Terms of Use
  • Cookies and Interest-Based Ads
  • Accessibility Statement
  • Cookie Preferences
Copyright © 2026 OpenTable, Inc. 1 Montgomery St Ste 500, San Francisco CA 94104 - All rights reserved.
OpenTable is part of Booking Holdings, the world leader in online travel and related services.
Booking Logo
Priceline Logo
KAYAK Logo
Agoda Logo
OpenTable Logo